全文获取类型
收费全文 | 10740篇 |
免费 | 873篇 |
国内免费 | 6篇 |
出版年
2023年 | 67篇 |
2022年 | 64篇 |
2021年 | 250篇 |
2020年 | 157篇 |
2019年 | 282篇 |
2018年 | 310篇 |
2017年 | 277篇 |
2016年 | 402篇 |
2015年 | 627篇 |
2014年 | 636篇 |
2013年 | 829篇 |
2012年 | 958篇 |
2011年 | 907篇 |
2010年 | 557篇 |
2009年 | 540篇 |
2008年 | 653篇 |
2007年 | 665篇 |
2006年 | 563篇 |
2005年 | 507篇 |
2004年 | 448篇 |
2003年 | 404篇 |
2002年 | 371篇 |
2001年 | 96篇 |
2000年 | 61篇 |
1999年 | 76篇 |
1998年 | 86篇 |
1997年 | 55篇 |
1996年 | 54篇 |
1995年 | 68篇 |
1994年 | 63篇 |
1993年 | 43篇 |
1992年 | 55篇 |
1991年 | 42篇 |
1990年 | 28篇 |
1989年 | 42篇 |
1988年 | 25篇 |
1987年 | 27篇 |
1986年 | 29篇 |
1985年 | 32篇 |
1984年 | 20篇 |
1983年 | 30篇 |
1982年 | 14篇 |
1981年 | 12篇 |
1980年 | 18篇 |
1979年 | 24篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1976年 | 14篇 |
1974年 | 15篇 |
1968年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
Silene ichnusae (Caryophyllaceae) a new species of S. sect. Siphonomoipha is described and illustrated. It is a rare chasmophyte localized at Capo Falcone (W Sardinia), on siliceous rocks near the sea. Its relationships with S. velutina, of the S. mollissima group, are discussed. 相似文献
53.
Human Cytomegalovirus UL131-128 Genes Are Indispensable for Virus Growth in Endothelial Cells and Virus Transfer to Leukocytes 下载免费PDF全文
54.
Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. 相似文献
55.
56.
Giorgio Trinchieri Marek Kubin Graziella Bellone Marco A. Cassatella 《Journal of cellular biochemistry》1993,53(4):301-308
Cytokines represent one of the most important elements in the communication among different cell types. They play an increasingly better understood role in the communication among hematopoietic cells and in particular in the reciprocal regulation of effector cell types of innate or natural resistance (phagocytic cells and Natural Killer (NK) cells) and those of adaptive immunity (T and B lymphocytes). Lymphocytes produce several cytokines with either stimulatory (e.g., colony stimulatory factor) or suppressive (e.g., tumor necrosis factors and interferons) effects on proliferation of early hematopoietic cells. Many of these cytokines, alone or acting in synergistic combinations, also have a differentiation-inducing ability on immature myeloid cells and act as powerful potentiators of the cellular functions of terminally differentiated phagocytic cells. The communication between lymphocytes and phagocytic cells is not unidirectional, as phagocytic cells produce factors that regulate lymphocyte activation. In addition to their role as antigen presenting cells expressing costimulatory accessory molecules and secreting cytokines (e.g., IL-1, IL-6, TNF), phagocytic cells have been recently shown to produce Natural Killer cell Stimulatory Factor (NKSF/IL-12). IL-12 is a heterodimeric cytokine with important modulatory functions on cytotoxicity of NK and T cells, lymphocyte proliferation, lymphokine production, and development of T helper cell subsets. These communications between phagocytic cells and lymphocytes are further regulated by negative and positive feedback mechanisms that contribute to maintain the homeostasis of the system in physiologic conditions and to govern the changes in this equilibrium needed for the response to infectious or other foreign agents. 相似文献
57.
Nicola Migone Sergio Padovan Claudio Zappador Claudia Giachino Marco Bottaro Giuseppe Matullo Caterina Carbonara Gennaro De Libero Giulia Casorati 《Immunogenetics》1995,42(5):323-332
To determine whether the limited V gene usage by the T-cell receptor delta (TCRD) chain is dictated by preferential rearrangement or by antigen selection, we characterized and compared the TCRDV gene repertoire of the productive with that of the unprotective allele in 80 human TCRG/TCRD clones. Six different V genes were found on the expressed allele; two of them, provisionally named DV7 and DV8, have not been described before on the surface of TCRG/TCRD T cells. Overall, six V genes and six non-V elements were isolated from the unproductive allele. Interestingly, the same set of genes was rearranged both in the productive and in the unproductive chromosome. These findings seem to suggest that antigen-independent mechanisms play a major role in the restriction of the TCRDV gene repertoire.The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide database and have been assigned the accession numbers Z46643 (DV7-E2), Z46644 (DV8-E6), Z46645 (DV8-M1), Z46641 (AV12-E4), Z46642 (AV29-E5), Z46652 (DREC-E13), Z46637 (TCR-d), Z46638 (TCR-n), Z46639 (TCR-r), Z46653 (PSI-DVu), and Z46640 (TCR-w) 相似文献
58.
59.
The interplay of riverscape features and exotic introgression on the genetic structure of the Mexican golden trout (Oncorhynchus chrysogaster), a simulation approach 下载免费PDF全文
60.
Oliveira Jairo P. Prado Adilson R. Keijok Wanderson J. Valotto Rafaela S. Silva André R. Guimarães Marco C. C. 《Plasmonics (Norwell, Mass.)》2019,14(3):743-753
Plasmonics - Nano-surface modification techniques have been increasingly reported in a multitude of applications. However, the metal-ligand interface can be difficult to characterize, mainly due to... 相似文献